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Jason Winget
Senior Scientist, Proteomics, LC-MS/MS, and Data Science
I am a PhD biochemist with 10 years of experience in proteomics, including quantitative shotgun and targeted approaches. I am a strong advocate for reproducible research and data integrity. My recent professional development has focused on best statistical practices for data analysis and interpretation, as well as clear and transparent communication of results.
I am particularly interested in opportunities with dynamic and energetic teams which leverage data science (statistical analysis and modeling) to provide deeper insights that address biological questions about mechanism of action and health.
Professional Experience
Senior Scientist
Procter & Gamble
Mason, OH, USA
Present - 2019
- Technical lead for corporate proteomics program
- Studied effects of cosmetics usage on epidermal health
- Developed internal capability in Data-Independent Analysis (DIA)
- Performed small organic chemical constitutent identification (CCID) to support current business needs
- Leveraged proteogenomics to support naturals & botanicals program for Type I allergy program
- Developed R Shiny applications and Rmarkdown templates to streamline repetitive data analysis tasks
Scientist
Procter & Gamble
Mason, OH, USA
2019 - 2016
- Developed high throughput targeted proteomics assays to support clinical studies.
- Spearheaded adoption of label-free proteomics approaches to refine safety assessments for Type-I allergy
- Harmonized sample preparation, LC-MS/MS methods, and data analysis across studies
- Taught “Introduction to R” courses
Research Scientist
Institute for Systems Biology
Seattle, WA, USA
2016 - 2014
- Performed shotgun and targeted proteomic analysis of human epidermis
- Developed software for label-free quantification
Postdoctoral Researcher
Institute for Systems Biology
Seattle, WA, USA
2014 - 2012
- Method development for proteomic analysis of low protein yield clinical skin surface samples
- Refined data processing parameters for samples containing highly homologous proteins
Postdoctoral Fellow
University of British Columbia
Vancouver, BC, Canada
2012 - 2009
- Studied the ubiquitin & proteasome system
- Mammalian cell culture
- Immunofluorescence
- Site-directed mutagenesis
- Mentored several undergraduate researchers
Education
University of Delaware
Ph.D. in Biochemistry
Newark, DE, USA
2009 - 2002
Thesis advisor: Dr. Brian Bahnson. Research involved structural biology of G protein-coupled receptors and Phospholipase A2 membrane-associated enzymes. Awarded an NSF Integrative Graduate Research Traineeship (IGERT).
Florida State University
B.Sc. in Chemistry
Tallahassee, FL, USA
2002 - 1998
Selected Publications
Proteomic and bioinformatic analyses for the identification of proteins with low allergenic potential for hazard assessment
Toxicological Sciences 170 (1), 210-222
N/A
2019
Krutz NL, Winget JM, Ryan CA, Wimalasena R, Maurer-Stroh S, Dearman RJ, Kimber I, Gerberick GF
StPeter: Seamless label-free quantification with the trans-proteomic pipeline
Journal of proteome research 17 (3), 1314-1320
N/A
2018
Hoopmann MR, Winget JM, Mendoza L, Moritz RL
Quantitative proteomic analysis of stratum corneum dysfunction in adult chronic atopic dermatitis
The Journal of investigative dermatology 136 (8), 1732
N/A
2016
Winget JM, Finlay D, Mills KJ, Huggins T, Bascom C, Isfort RJ, Moritz RL
Quantitative proteogenomic profiling of epidermal barrier formation in vitro
Journal of dermatological science 78 (3), 173-180
N/A
2015
Winget JM, Watts JD, Hoopmann MR, DiColandrea T, Robinson MK, Huggins T, Bascom C, Isfort RJ, Moritz RL
The diversity of ubiquitin recognition: hot spots and varied specificity
Molecular cell 38 (5), 627-635
N/A
2010
Winget JM and Mayor T